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BAFF-R deficiency

Immunologic phenotype

T cells

Both BAFF-R deficient patients presented with normal T cell numbers, CD4/CD8 ratio and T cell subpopulations. No information are available on Tregs and TH17 populations in BAFF-R deficiency which is however unlikely.

Population Marker Altered phenotype * Relative counts ** Absolute counts **
Total T cells   CD3 n n n
CD4+ T cells   3+ 4+ n n n
Naive CD4+   3+ 4+ 45RA+ n n n
Memory CD4+   3+ 4+ 45RO+ n n n
CXCR5+ CD4   3+ 4+ 45RO+ CXCR5+ n n n
Recent thymic emigr.   3+ 4+ 45RA+ 31+ ? ? ?
T reg   4+ 127- 25++ ? ? ?
Th17   4+ IL17+ ? ? ?
CD8 T cells   3+ 8+ n n n
Naive CD8 T cells   3+ 8+ 27+ 28+ n n n
Early effector CD8   3+ 8+ 27+28+ n n n
Late effector CD8   3+ 8+ 27- 28- n n n
Double negative Tc   3+ a/b+ 4- 8- ? ? ?
Gamma/Delte Tc   3+ g/d+ n n n

Legend:

*) Altered phenotype:
Phenotype of respective population is altered compared to adult controls:
y = yes y = no v = variable ? = no information available
**) in all other fields the choices are:
n = normal + = expanded ++ = severely expanded ? = no information available
v = variable - = decreased -- = severely decreased --- = absent
Last update: 2010-05-11 10:53:52

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